Chronic idiopathic urticaria has been anecdotally linked to stress since the 1940s.

When treating chronic idiopathic urticaria, the liquid may be used in children as young as 2 months old.

Sulfasalazine has also been used successfully to treat cases of idiopathic urticaria that do not respond to antihistamines.

In perhaps as many as 30-40% of patients with chronic idiopathic urticaria, it is caused by an autoimmune reaction.

In the past decade, many cases of chronic idiopathic urticaria have been noted to be the result of an autoimmune trigger.

Most cases are called chronic idiopathic urticaria, which means they're caused by the body's unexplainable development of antibodies to itself (auto-antibodies).

Doxepin is used to treat depression, anxiety disorders, and as a second line treatment of chronic idiopathic urticaria (hives).

Ebastine in allergic rhinitis and chronic idiopathic urticaria.

Chronic idiopathic urticaria, which causes daily or almost daily raised red bumps (wheals) and itching for at least 6 weeks without a known cause.

Fexofenadine is also used to treat skin itching and hives caused by a condition called chronic idiopathic urticaria in adults and children.

Ebastine is a second-generation H1 receptor antagonist that is indicated mainly for allergic rhinitis and chronic idiopathic urticaria.

Histamine release (HR) - especially helpful in identifying allergic reactions that don't involve IgE and can also help diagnose idiopathic urticaria.

Some cases of self-diagnosed Morgellons disease are actually other recognized skin disorders, including allergic contact dermatitis, contact dermatitis, idiopathic urticaria and infestation with the parasite scabies.

In clinical research, bilastine has proven to be well tolerated, with an adverse events profile similar to that of placebo in healthy volunteers, patients with AR and with chronic idiopathic urticaria.

Using this approach, the role played by dietary chemical factors in the pathogenesis of chronic idiopathic urticaria (CIU) was first established and set the stage for futute DBPCT trials of such substances in food intolerance studies.

A recent study has demonstrated an association between stressful life events (e.g. bereavement, divorce, etc.) and chronic idiopathic urticaria and also an association between post-traumatic stress and chronic idiopathic urticaria.

The relatively recent clinical trial results, which indicate that omalizumab has excellent effects on patients with recalcitrant, antihistamine-resistant chronic idiopathic urticaria, including those cases of autoimmune cause, have generated much excitement among dermatologists as well as patients affected by chronic urticaria.

In a Phase III trial whose results were published early 2013 online in The New England Journal of Medicine, the anti-asthma drug omalizumab showed promise in relieving itchiness for patients with chronic idiopathic urticaria whose symptoms were not relieved with antihistamine treatment.