Many of these hypothalamic hormones act on the pituitary gland.

The neurohypophysis stores and releases two hypothalamic hormones:

They also regulate many hormones including pituitary, gonadal and hypothalamic hormones as well as insulin.

Hypothalamic hormones are secreted to the anterior lobe by way of a special capillary system, called the hypothalamic-hypophysial portal system.

This, however, raised the question whether the hypothalamic factor had a direct effect on the teeth or rather had an indirect effect characteristic of other hypothalamic hormones.

Hypothalamic hormones are produced in hypothalamus nuclei then transported along axons to either the median eminence or the posterior pituitary, where they are stored and released as needed.

Dr. Gerald T. Schelling and colleagues at Texas A & M University are tackling growth hormone from another angle: immunizing animals against a hypothalamic hormone, somatostatin, that normally inhibits growth hormone release.

At the Salk, he conducted studies and published with Guillemin on the cell biology and mode of action / structure-activity relationships of hypothalamic hormone analogs and was a co-discoverer of the hypothalamic peptide, Somatostatin.

In 1998 he received the Monsanto Clinical Investigator Award from the Endocrine Society in recognition of his contribution in the field of hypothalamic hormones and his discovery of the GHRP pathway and its clinical and therapeutic importance.