Hypersecretion of prolactin is more common than hyposecretion.

Hyposecretion results in diabetes insipidus.

Endocrine gland hyposecretion (leading to hormone deficiency)

If the cause is prepubescent hyposecretion of growth hormone, supplemental growth hormone may correct the abnormality.

Graves' disease is the most common cause of hyperthyroidism; hyposecretion causes cretinism in infants and myxoedema in adults.

Hyposecretion of insulin results in diabetes mellitus; cardinal signs are polyuria, polydipsia, and polyphagia.

Endocrine disorders are often quite complex, involving a mixed picture of hyposecretion and hypersecretion because of the feedback mechanisms involved in the endocrine system.

Hypofunction of endocrine glands can occur as a result of loss of reserve, hyposecretion, agenesis, atrophy, or active destruction.

Chey et al found hyposecretion of gastric acid or achlorhydria in chronic alcoholic patients without clinical or laboratory evidence of pancreatic disease.

Hypersecretion causes gigantism in children and acromegaly in adults; hyposecretion in children causes pituitary dwarfism.

The aqueous tear layer is affected, resulting in aqueous tear deficiency (ATD) or lacrimal hyposecretion.

Hypopituitarism, the hyposecretion of ACTH in the pituitary, leading to secondary adrenal insufficiency (a form of hypocorticism)

Other abnormalities include reduced responsivity of thyrotropin and thyroid hormones to thyroid-releasing hormone, a mild elevation of prolactin levels with disinhibition of prolactin release in response to challenge and hyposecretion of adrenal androgens.