In severe inflammation there may be evidence of a hypopyon.

This is due to the effect of gravity, hence the name inverse hypopyon.

Hypopyon can be present in endophthalmitis and should be looked for on examination by a slit lamp.

Small satellite lesions around the ulcer are a common feature of fungal keratitis and hypopyon is usually seen.

An inverse hypopyon needs to be differentiated from a standard hypopyon.

Compare from the hypopyon resulting due to the toxins where the leukocytes settle at the bottom of the anterior chamber.

"Saemisch's operation": An operation for hypopyon ulcer.

Common findings on anterior segment slit lamp examination include increased cell and flare with associated fibrin and possible hypopyon formation.

There is almost invariably a secondary uveitis present with corneal ulceration, and signs of this may also be seen: miosis, corneal oedema, aqueous flare, hypopyon, IOP changes.

Anterior uveitis presents with painful eyes, conjuctival redness, hypopyon, and decreased visual acuity, while posterior uveitis presents with painless decreased visual acuity and visual field floaters.

Inverse hypopyon is seen sometimes after a pars plana vitrectomy with insertion of silicon oil (as a replacement of the vitreous humour that has been removed in the operation; the silicon oil maintains internal tamponade).

During the annual meeting of the Medical Society of Athens on November 15, 1930, Adamantiades presented "A case of relapsing iritis with hypopyon" identifying the three major signs of the so-called Adamantiades-Behçet's disease and insisting on a single clinical entity.