orexin
hypocretin

For example, the same researchers have also recently shown similar findings with another brain chemical called orexin.

Orexin A is a promising candidate to become a "sleep replacement" drug.

Orexin plays a greater role in controlling the relationship between eating and sleeping.

The orexin system may thus be more important in the regulation of energy expenditure than food intake.

Orexin, as of 2007, is claimed to be a very important link between metabolism and sleep regulation.

Others point to the Greek root "orexin" which means appetite or appetizing.

Deficiency in orexin has also been linked to narcolepsy, a sleep disorder.

Preliminary research has been conducted that shows potential for orexin blockers in the treatment of alcoholism.

And when they blocked orexin, these levels decreased.

Sleep advocates probably won't have to worry about orexin A reaching drugstore shelves for many years.

He also points out that being anxious or in pain, both conditions associated with poor sleep, are linked with lower levels of orexin.

However, it is unknown how glucose suppresses the electrical activity of orexin cells.

The control of wakefulness has recently been found to be strongly influenced by the newly discovered protein orexin.

Orexin deficiency has been identified as responsible for narcolepsy.

Narcolepsy is due to a decrease in orexin.

The protein produced, called hypocretin or orexin, is responsible for controlling appetite and sleep patterns.

The orexin neuropeptide signaling system is a central promoter of wakefulness.

"Our study did show minor impairment of normal performance with relatively high systemic doses of orexin."

Holtzman said the findings suggest drugs that target orexin may be useful to try as Alzheimer's treatments.

Also known as orexin because two different groups discovered it simultaneously, for years it was primarily associated with sleep and appetite.

Several orexin receptor antagonists are in development for potential use in sleep disorders.

After switching off the blue light, the hypothalamic orexin neurons showed activity for several tens of seconds.

In conjunction, these genetic anomalies cause the immune system to attack and kill the critical orexin neurons.

Orexin increases the craving for food, and correlates with the function of the substances that promote its production.

In normal-weight mice, activation of this receptor decreases orexin A release.

However, in humans, we did not know why the hypocretin cells die.

Their hypocretin cells, it turns out, are not wired like those in mammals.

He predicts that at best a hypocretin stimulating drug will be created in 5 to 10 years.

Some scientists think that narcolepsy is caused by a lack of hypocretin.

The reason is that patients have lost 90 percent of the brain cells that make hypocretin.

There is limited evidence of what role hypocretin may play, although it often influences hypersomnia.

He has turned to zebrafish, which possess hypocretin and hatch rapidly.

Such overlapping functions may also mean that hypocretin research could open up new understanding about addictions as well.

Doctors can now extract spinal fluid and test for hypocretin to make a diagnosis.

Blocking hypocretin, however, prevents the animals from developing this addiction-like behavior.

None of the medicines influence the hypocretin system.

The discovery of the hypocretin deficiency a decade ago was key to understanding the mechanism behind the symptoms.

That suggests that drugs to block hypocretin might hold promise for addiction treatment.

The few cases with a genetic origin that have been tested so far, like the López family, also show no hypocretin.

The findings also suggest that hypocretin deficiency may underlie depression from other causes.

While these drugs can help alleviate the symptoms, they do not address the underlying problem of hypocretin deficiency.

He still plans to explore the cell biology of zebrafish hypocretin neurons.

The task now is to try to find a link between myelin in the central nervous system and hypocretin deficiency.

Siegel noted that hypocretin antagonists are now being developed by several drug companies for use as sleeping pills.

Research also suggests that hypocretin is involved in regulating muscle tone, metabolism and feelings of pleasure.

The protein produced, called hypocretin or orexin, is responsible for controlling appetite and sleep patterns.

Research in animals linked hypocretin to the craving for pleasurable experiences provided by drugs and high fat foods.

The regulation of hypocretin expression by the circadian system:

These lesions or generalized processes disrupt the hypocretin neurons and their pathways.

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.