hirudin

Full length hirudin is made up of 65 amino acids.

Bleeding may continue for some time, due to the leech's hirudin.

The procedure lasted only 15 minutes, and hirudin served as the anticoagulant.

However, recombinant techniques can be used to produce homogeneous preparations of hirudin.

One of these, hirudin, found in the European leech, inhibits blood clotting.

This is a function of the hirudin and other compounds that reduce the surface tension of the blood.

Natural hirudin contains a mixture of various isoforms of the protein.

Hirudin is the most potent natural inhibitor of thrombin.

Several other direct thrombin inhibitors are derived chemically from hirudin.

It is almost identical to hirudin extracted from Hirudo medicinalis.

One such drug, hirudin, was derived from the European leech that used the chemical to keep its victim's blood flowing.

The three studies aimed in part at comparing heparin, which was discovered in 1916, and hirudin.

The active anticoagulant component of leech saliva is a small protein, hirudin.

The first DTI was actually hirudin, which became more easily available with genetic engineering.

Lepirudin is a recombinant hirudin derived from yeast cells.

Bivalirudin, a 20 amino acid polypeptide, is a synthetic analog of hirudin.

The wound will also continue to bleed for a while due to the anticoagulant hirudin in the leeches' saliva.

With technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs.

Hirudin and derivatives were originally discovered in Hirudo medicinalis:

Native hirudin, a 65-amino-acid polypeptide, is produced in the parapharyngeal glands of medicinal leeches.

It turns out that the business-end of thrombin, called the active site, is plugged by the hirudin, preventing blood clotting.

'It turns out that pieces of hirudin have different inhibitory properties with different side-effects,' Huber said.

In the clinical assay, a known quantity of ecarin is added to the plasma of a patient treated with hirudin.

Thus, the ECT is prolonged in a specific and linear fashion with increasing concentrations of hirudin.

After piercing the skin and injecting anticoagulants (hirudin) and anaesthetics, they suck out blood.