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One compound in this herb, called harmine, may cause euphoria.
The stems and leaves of C. antifebrile have been reported to contain harmine.
Harmine is found in a wide variety of different organisms, most of which are plants.
It is the reduced hydrogenated form of harmine.
Serum or plasma harmine concentrations may be measured as a confirmation of diagnosis.
The coatings of the seeds are said to contain large amounts of harmine.
The stems contain 0.11-0.83% beta-carbolines, with harmine and tetrahydroharmine as the major components.
The effects are thought to be attributable to the action of harmine, a very stable indole that is the active principle in the plant.
Harmine is also a useful fluorescent pH indicator.
As the pH of its local environment increases, the fluorescence emission of harmine decreases.
So, harmine and harmaline are reversible selective inhibitors of monoamine oxidase-A.
Dr. Alexander Shulgin has suggested that harmine may be a breakdown product of harmaline.
Isolated harmine was found to exhibit a cytotoxic effect on HL60 and K562 leukemic cell lines.
Individual polymorphisms in the cytochrome P450-2D6 enzyme affect the ability of individuals to metabolize harmine.
The three most studied harmala alkaloids in the B. caapi vine are harmine, harmaline and tetrahydroharmine.
One harmala alkaloid present in this herb in the form of harmine is thought to induce meditative and euphoric effects.
Simple (non-isoprenoid) β-carboline derivatives include harmine, harmaline, harmane and a slightly more complex structure of canthinone.
Both the plant and the extract harmine exhibit cytotoxicity with regards to HL60 and K562 leukemia cell lines.
The purely synthetic MAO inhibitor Marplan is also suitable in place of harmaline and harmine.
The capsules with harmaline/harmine is swallowed first and the capsule containing the DMT is taken some fifteen to twenty minutes later.
With the radioisotope carbon-11 harmine is used in positron emission tomography neuroimaging to examine its binding to MAO-A.
Consequently, the harmala alkaloids (including harmine) are unlikely to elicit tyramine-mediated hypertensive crisis, and a special diet does not need to be so strictly adhered to.
In the formation of simple β-carboline alkaloids, such as harmine and harmaline, pyruvic acid acts as the keto acid.
He has been working with positron emission tomography using the DASB, setoperone and harmine radioligands to examine neuropsychiatric disorders.
It contains harmine, harmaline, and tetrahydroharmine, all of which are both beta-carboline harmala alkaloids and MAOIs.