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Guaiacol can be prepared by diverse routes in the laboratory.
Chemically, it is an ester resulting from the combination of aspirin and guaiacol.
Guaiacol is one of the molecules responsible for the cork taint wine fault.
The second ring is introduced with guaiacol.
Guaiacol is produced in the gut of Desert locusts by the breakdown of plant material.
Guaiacol is present in wood smoke, resulting from the pyrolysis of lignin.
Guaiacol is one of the main components of the pheromones that cause locust swarming.
Several routes exist for synthesizing vanillin from guaiacol.
In preparation of food by smoking, syringol is the main chemical responsible for the smoky aroma, while guaiacol contributes mainly to taste.
Guaiacol is a precursor to various flavorants such as eugenol and vanillin.
It is the monomethyl ether of hydroquinone, and an isomer of guaiacol.
In 1876, Karl Reimer synthesized vanillin (2) from guaiacol (1).
However, unlike vanillin synthesized from lignin or guaiacol, it can be labeled as a natural flavoring.
Condensations with guaiacol in place of phenol provides a route to vanillin, a net formylation.
It is compounded of guaiacol, phenols, cresol, xylenol and creosol.
Isoeugenol is a phenylpropene, a propenyl-substituted guaiacol.
Wood can be used to produce guaiacol, tar, terpenes, turpentine and methanol together with a solid residue of charcoal.
Its biosynthesis entails the enzyme-catalyzed methylation of guaiacol (methoxyphenol).
Eugenol is a phenylpropene, an allyl chain-substituted guaiacol.
Of those, the most important are guaiacol and syringol and their derivatives; their presence can be used to trace a smoke source to a wood fire.
Together with guaiacol, syringol and its derivates are characteristic products of pyrolysis of lignin.
Today, artificial vanillin is made either from guaiacol or from lignin, a constituent of wood, which is a byproduct of the pulp industry.
Guaiacol is the phenolic compound most responsible for the "smokey" taste, while syringol is the primary contributor to smokey aroma.
In industry, guaiacol is produced by methylation of catechol, e.g. using potash and dimethyl sulfate:
Guaiacol can be synthesized by the di methylation of catechol followed by selective mono-demethylation.