Additionally, two formylation reactions occur in the de novo biosynthesis of purines.

Rieche formylation is a type of formylation reaction.

Leigh syndrome is a neurodegenerative disorder that has been linked to a defect in an enzymatic formylation reaction.

In a related reaction, formyl chloride is implicated in Gattermann-Koch formylation reaction.

In some formylation reaction of alkyllithium compounds, N-formylpiperidine gives higher yields than the DMF.

Aromatic formylation reactions via electrophilic aromatic substitution include:

This further indicating that formyl phosphate may be an intermediate, as it is kinetically and chemically competent to carry out the formylation reaction in the enzyme.

Therefore, the N5 nucleophile of AIRCAR must be activated for the formylation reaction to occur.

The formylation reaction is proposed to occur through a direct transfer reaction in which the amine group of GAR nucleophillically attacks N10-formyl-THF creating a tetrahedral intermediate.

Several folate based inhibitors have been developed to inhibit formylation reactions by GAR transformylase and AICAR transformylase.

The Duff reaction or hexamine aromatic formylation is a formylation reaction used in organic chemistry for the synthesis of benzaldehydes with hexamine as the formyl carbon source.

Two formylation reactions are required in the eleven step de novo synthesis of inosine monophosphate (IMP), the precursor of the purine ribonucleotides AMP and GMP.

Other reactions that follow an electrophilic aromatic substitution pattern are a group of aromatic formylation reactions including the Vilsmeier-Haack reaction, the Gattermann Koch reaction and the Reimer-Tiemann reaction.

Another pyrolysis gave tetrabridged cyclophane 7, another formylation reaction gave dialdehyde 8, another reduction/chlorination sequence gave dichloride 9, and a final pyrolysis gave superphane 10 as hard white crystals with melting point 325-327 C.

The compound is then subjected to a formylation reaction (the Vilsmeier-Haack reaction), which uses dimethylformamide in the presence of phosphorus oxychloride to attach a formyl group to the site on the arene ring which was opened by the previous reaction.