Follicular hyperplasia is a stimulation of the B cell compartment.

Follicular hyperplasia - Seen in infections, autoimmune disorders, and nonspecific reactions.

Biopsies of the ileum were reported to have shown reactive lymphoid follicular hyperplasia in seven.

Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerous mitotic figures.

Slight reactive changes were seen in the lymph nodes, dominated by follicular hyperplasia in the peripheral and sinus histiocytosis in the mesenteric ones.

Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles).

Proliferation of FDC cells is characteristic of many neoplastic conditions including follicular hyperplasia, follicular lymphoma, nodular lymphocyte predominate Hodgkin's disease and angioimmunoblastic T-cell lymphoma.

The regional lymph nodes demonstrate follicular hyperplasia with central stellate necrosis with neutrophils, surrounded by palisading histiocytes (suppurative granulomas) and sinuses packed with monocytoid B cells, usually without perifollicular and intrafollicular epithelioid cells.