extrapyramidal syndrome

Extrapyramidal syndrome is when involuntary muscle movements occur in the face and neck.

In 1969, the drug was also discovered by accident to help reduce symptoms of Parkinson's disease, drug-induced extrapyramidal syndromes, and akathisia.

Extrapyramidal syndrome (EPS) is due to the blockade of dopamine receptors in the basal ganglia, leading to Parkinson-like symptoms such as slow movement (bradykinesia), stiffness, and tremor.

Officially, the only hint to date that the Pope may suffer from a neuro degenerative disease was a reference to an "extrapyramidal syndrome" that first appeared in a medical bulletin in August.

In Phase III trial for schizophrenia, 66.7 % of patients experienced these side effects, as well as other issues such as metabolic problems, extrapyramidal syndrome (EPS) side effects, and sedation.

It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

Woodhouse-Sakati syndrome, also called hypogonadism, alopecia, diabetes mellitus, mental retardation and extrapyramidal syndrome, is a rare autosomal recessive multisystem disorder which causes malformations throughout the body, and deficiencies affecting the endocrine system.

Cariprazine's high selectivity towards D3 receptors could prove to reduce side effects associated with the other antipsychotic drugs, because D receptors are mainly located in the ventral striatum and would not incur the same motor side effects (extrapyramidal syndrome) as drugs that act on dorsal striatum dopamine receptors.