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The new agent anagrelide (Agrylin) has recently been introduced for the treatment of essential thrombocytosis.
Essential thrombocytosis patients who are suitable for anagrelide often meet one or more of the following factors:
Anagrelide is used to treat essential thrombocytosis, especially when the current treatment of the patient is insufficient.
Other chronic myeloproliferative syndromes such as polycythemia vera and essential thrombocytosis are extremely rare in children.
Essential thrombocytosis (a form of myeloproliferative disease)
This process may also be used therapeutically to treat disorders resulting in extraordinarily high platelet counts such as essential thrombocytosis.
Myeloproliferative disease (primarily polycythemia vera and essential thrombocytosis).
Essential thrombocytosis can be linked with increased risk of spontaeous abortion or miscarriage in the first trimester of pregnancy.
Essential thrombocytosis is sometimes described as a slowly progressive disorder with long asymptomatic periods punctuated by thrombotic or hemorrhagic events.
Non-cancerous overproduction of red cells (polycythemia vera) or platelets (essential thrombocytosis) may be premalignant.
It is usually reactive following other myeloproliferative disorders, such as polycythemia vera, chronic myeloid leukemia or essential thrombocytosis.
The PT1 study compared hydroxyurea in combination with aspirin to anagrelide in combination with aspirin as initial therapy for essential thrombocytosis.
Essential thrombocytosis (ET-Also known as Essential thrombocythemia) is a disorder characterized by extremely high numbers of circulating platelets.
Anagrelide (Agrylin/Xagrid, Shire) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets.
Similarly, myeloproliferative disorders, in which the bone marrow produces too many blood cells, predispose to thrombosis, particularly in polycythemia vera (excess red blood cells) and essential thrombocytosis (excess platelets).
ET essential hemorrhagic thrombocythemia essential thrombocytosis idiopathic thrombocythemia idiopathic thrombocytosis primary thrombocythemia None Essential thrombocythemia (ET) is a rare, chronic disorder characterized by the overproduction of platelets.
Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytosis (erythromelalgia can also develop in the presence of normal platelet counts in patients with myeloproliferative disorder), hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders.