epsilon chain

More specifically, otelixizumab targets the epsilon chain of CD3.

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B, CD3EAP and NCK2.

It binds to the T cell receptor-CD3-complex (specifically the CD3 epsilon chain) on the surface of circulating T cells, initially leading to an activation, but subsequently inducing blockage and apoptosis of the T cells.