enzyme induction

This is the opposite of enzyme induction, which triggers or increases production.

This form of gene regulation is called enzyme induction and inhibition.

Smoking can decrease the effectiveness of this drug (through liver enzyme induction).

In fact, people taking these drugs have displayed the highest degree of hepatic enzyme induction on record.

By enzyme induction it can reduce efficacy of haloperidol & oral contraceptives.

Other reversible early effects noted were peripheral neuropathy and liver enzyme induction.

Liver weight changes were not associated with microscopic lesions and were thought to result from enzyme induction.

Smoking has been shown to enhance the elimination rate of toluene from the body, perhaps as a result of enzyme induction.

This enzyme induction occurs at therapeutic doses.

Hence, there is no response to treatment with phenobarbital (which causes CYP450 enzyme induction).

Another potential treatment is phenobarbital, which is believed to accelerate the metabolism of some anticoagulants via enzyme induction.

Effects of microsomal enzyme induction on the toxicity of pyrrolizidine (Senecio) alkaloids.

From a biomedicinal perspective, the therapeutic value of Kalmegh is due to its mechanism of action which is perhaps by enzyme induction.

The exact clinical significance of this Enzyme induction and inhibition and its therapeutic consequences are unknown at present time and remain to be evaluated.

Hepatic microsomal enzyme induction, altered lacrimation, menorrhagia, hyperkinesia, hypoesthesia and angioneurotic edema.

As a result of these interactions the function of the enzymes can either be stimulated (enzyme induction) or inhibited (enzyme inhibition).

The only microscopic lesion seen in mice was centrilobular hepatocellular hypertrophy, observed in two high-dose females and considered due to enzyme induction.

St. John's wort also has been shown to cause drug interactions through the Enzyme induction and inhibition of the P-glycoprotein efflux transporter.

Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme.

These effects are called enzyme induction and inhibition and are alterations in gene expression, which is unrelated to the type of enzyme inhibition discussed here.

In general, anything that increases the rate of metabolism (e.g., enzyme induction) of a pharmacologically active metabolite will decrease the duration and intensity of the drug action.

However, in cases where an enzyme is responsible for metabolizing a pro-drug into a drug, enzyme induction can speed up this conversion and increase drug levels, potentially causing toxicity.

Tests on laboratory animals show that the primary effects after long term exposure to dicofol include increases in liver weight and enzyme induction in the rat, mouse and dog.

A study where pregnant rats fed were about 47 times the usual human dose of 26 mg/kg concluded, "Maternal liver weights were increased at 6250 ppm, suggesting possible enzyme induction.