As such enantioselective synthesis is of great importance; but it can also be difficult to achieve.

The reason for this is historical, as at the time enantioselective synthesis was seen in terms of vitalism.

However it raised the importance of chirality in drug design, leading to increased research into enantioselective synthesis.

It is one of several strategies in enantioselective synthesis and of some relevance to academic research.

In other cases, enantioselective syntheses have been developed.

This can meet the criteria for enantioselective synthesis when a new chiral species is created, such as in an S2 reaction.

This experimental catalyst was effective for enantioselective synthesis, achieving a modest 15% enantiomeric excess.

Apart from enantioselective synthesis, chiraly pure materials can be obtained by chiral resolution.

The development of enantioselective synthesis was initially slow, largely due to the limited range of techniques available for their separation and analysis.

The presence of the cyclopropane motif in a number of drug molecules has made the development of enantioselective synthesis important.

Together with the Shi epoxidation, these reactions are useful for the enantioselective synthesis of chiral epoxides.

An enantioselective synthesis employs L-proline as an organocatalyst:

Aza-Baylis-Hillman reaction, for the use of a chiral ionic liquid in enantioselective synthesis.

The Josiphos ligands, often called privileged ligands, are importance because of their ability to give high yields in enantioselective synthesis.

In 1990, Barry Trost presented an enantioselective synthesis of rocaglamide in 18 steps and confirmed its absolute configuration.

However, despite its prevalence asymmetric induction is not always required for enantioselective synthesis, with the most obvious example being in chiral pool synthesis.

It is very commonly encountered, as it is effective for a broader range of transformations than any other method of enantioselective synthesis.

Perhaps the most versatile example of enantioselective synthesis is asymmetric hydrogenation, which is able to reduce a wide variety of functional groups.

Chiral pool synthesis is one of the simplest approaches for enantioselective synthesis, as it does not involve asymmetric induction.

In the first enantioselective synthesis of (+)-Griseofulvin, a potent antifungal agent, a Curtin-Hammett situation was observed.

Recently, a second, enantiocomplementary dirigent protein was identified in Arabidopsis thaliana, which directs enantioselective synthesis of (-)-pinoresinol.

A Josiphos ligand is a type of chiral diphosphine which has been modified to be substrate specific and is widely used for enantioselective synthesis.

This process also allows for enantioselective synthesis through the presence of chiral ligands or by adding chiral auxiliaries to the diazo compound.

Yamamoto reports the use of an alternative intramolecular Robinson annulation to provide a straightforward enantioselective synthesis of tetracyclic core of platensimycin.

The enantioselective synthesis was accomplished by J. K. Whitesell by adding Pseudomonas fluorescens lipase to racemic trans-2-phenylcyclohexyl chloroacetate.