Dysgammaglobulinemia is a type of immune disorder characterized by a reduction in some types of gamma globulins.

It was pretty rare a hereditary dysgammaglobulinemia affecting the beta fraction which he found in a family of four-but that was not important.

"Hypogammaglobulinemia" is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.

(The ratios of immunoglobulins vary rapidly in all infants, and the term dysgammaglobulinemia, although theoretically applicable, isn't usually used in this context.)

MeSH considers hyper IgM syndrome to be a form of dysgammaglobulinemia, not a form of hypergammaglobulinemia .

IgG deficiency (Selective deficiency of immunoglobulin G) is a form of dysgammaglobulinemia where the proportional levels of IgG are reduced relative to other immunoglobulin.

Chng HH, Shaw D, Klesius P, Saxon A. Inability of oral bovine transfer factor to eradicate cryptosporidial infection in a patient with congenital dysgammaglobulinemia.

Isolated primary immunoglobulin M deficiency (or selective IgM immunodeficiency (SIgMD)) is a poorly defined dysgammaglobulinemia characterized by decreased levels of IgM while levels of other immunoglobulins are normal.

Hyper IgM syndrome can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types.

Dysgammaglobulinemia Type I IHIS IMD3 Immunodeficiency with Increased IgM Immunodeficiency-3 HIM None Hyper-IgM Syndrome (HIM) is a rare genetic (primary) immunodeficiency disorder that is typically inherited as an X-linked recessive genetic trait.