Abscesses, draining fistulas and osteomyelitis may be associated with the nodules.

There is no clinically visible exposed necrotic bone, but a draining fistula or purulent secretion from the periodontal sulcus may exist.

If the infection is not controlled, the process becomes chronic and systemic symptoms are usually absent and draining fistulas, loosening of teeth and sequestra formation.

Symptoms include swelling or subareolar mass, a draining fistula from behind the areola, thick discharge from the nipple, or painful discharge.

Remicade was also shown to be effective in reducing the number of open, draining fistulas, a painful complication of Crohn's disease in which deep openings burrow from the bowel wall through the surface of the skin.

The FDA approved the drug for the treatment of moderate to severe Crohn's disease that does not respond to standard therapies (mesalamine substances, corticosteroids, immunosuppressive agents) and for the treatment of open, draining fistulas.