Antidepressant effectiveness varies, which may be related to different serotonergic and dopaminergic receptor binding profiles.

Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats.

Nevertheless, the greatest advantage of serotonin receptor antagonists over dopaminergic receptor antagonists is that they have fewer adverse effects.

In addition, they markedly decrease the severity of EPRs, especially akathisia, associated with dopaminergic receptor antagonist antiemetics.

Certain anti-parkisonian drugs, although targeted at dopaminergic receptors, cross-react with serotoninergic 5-HT receptors as well, and have been reported to cause cardiac fibrosis.

BZP has been shown to have a mixed mechanism of action, acting on the serotonergic and dopaminergic receptor systems in a similar fashion to MDMA.

Phenothiazines act on dopaminergic receptors at the CTZ, possibly at other central nervous system (CNS) centers, and peripherally.

Inverse agonists, such as haloperidol, or antagonists, such as risperidone, of dopaminergic receptors can also be used as an antidote for overdose of antipsychotic.

A 2009 study on rats has concluded that prenatal and neonatal exposure to low-dose BPA causes deficits in development at dorsolateral striatum via altering the function of dopaminergic receptors.

This relatively long half-life is considered to contribute to the compound's effectiveness in Parkinson's disease, particularly since it allows for more continuous stimulation of brain dopaminergic receptors than short-acting drugs such as levodopa.

Sato T, Meguid MM, Fetissov SO, Chen C, Zhang L. Hypothalamic dopaminergic receptor expressions in anorexia of tumor bearing rats.

Given the fact that the renal effects of low-dose dopamine in patients with sepsis syndrome decrease with time, it has been suggested that there is a desensitization of renal dopaminergic receptors [ 14].

Indeed, based on the canonical anatomofunctional model of basal ganglia, nigrostriatal dopamine is able to modulate the motor loop by acting on dopaminergic receptors located on striatal GABAergic medium spiny neurons.

As the user increases drug intake there is a destruction of dopaminergic receptors in the striatum which acts in addition to an impairment in goal-direction mental functions to produce an enhancement of sensitization to dopamine therapy.

Withdrawal-related psychosis from antipsychotics is called "supersensitivity psychosis", and is attributed to increased number and sensitivity of brain dopamine receptors, due to blockade of dopaminergic receptors by the antipsychotics, which often leads to exacerbated symptoms in the absence of neuroleptic medication.