dinitrobenzene

The dinitrobenzene is prepared by di nitration of benzene.

De Bruyn studied the three isomers of dinitrobenzene, setting the stage for the discovery of Meisenheimer complexes.

The 2-, 4-, and 6- positions on the pyrimidine ring are electron deficient analogous to those in pyridine and nitro- and dinitrobenzene.

In vivo experiment of DNBS (2,4 - dinitrobenzene sulfonic acid) induced rat colitis, a frequently used animal model for inflammatory bowel disease, showed comparable efficacy and increased potency than sulfasalazine.