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They are usually located at the dermoepidermal junction or in the dermis of the skin.
Apoptotic cells may be seen at the dermoepidermal junction.
Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.
Unclear events subsequently result in a separation along the dermoepidermal junction and eventually stretch bullae.
In skin, it is seen within the basement membrane of the dermoepidermal junction at points of nerve penetration.
This causes a weak dermoepidermal junction, where the epidermis easily separates from the dermis causing much pain.
Histopathologically, there is inflammation at the dermoepidermal junction and degeneration of the basal cell layer.
The dermoepidermal junction is the area of tissue that joins the epidermal and the dermal layers of the skin.
Stevens-Johnson syndrome and toxic epidermal necrolysis are diseases where there is a breakdown of the dermoepidermal junction.
Blister formation of EBS occurs at the dermoepidermal junction.
MCC is an aggressive neuroendocrine carcinoma arising in the dermoepidermal junction (see Figure 1).
Collagen is damaged and degraded and reticulin fibers appear throughout the dermis rather than outlining the specific dermoepidermal junction.
Lupus band test is done upon skin biopsy, with direct immunofluorescence staining, in which, if positive, IgG and complement depositions are found at the dermoepidermal junction.
Staining with anti-type IV collagen antibodies or anti-type VII collagen antibodies reveals bright, thick bands at the dermoepidermal junction.
Epidermolysis bullosa acquisita is a chronic subepidermal blistering disease associated with autoimmunity to type VII collagen within anchoring fibril structures that are located at the dermoepidermal junction.
Typical histological criteria of TEN include mild infiltrate of lymphocytes which may obscure the dermoepidermal junction and prominent cell death with basal vacuolar change and individual cell necrosis.
They have thickening of the stratum corneum (hyperkeratosis), thickening of the stratum spinosum (acanthosis), thickening of the stratum granulosum, rete ridge elongation, and large blood vessels at the dermoepidermal junction.
Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis.