One such alteration is decreased affinity for Cyclic guanosine monophosphate.

It acts by inhibiting the enzyme cyclic guanosine monophosphate phosphodiesterase.

Sensitivity to light is modulated by changes in intracellular calcium ions and cyclic guanosine monophosphate.

Cyclic guanosine monophosphate (cGMP) plays an important role in visual transductions.

It exerts its effects by binding to cytosolic guanylate cyclase and stimulating the production of cyclic guanosine monophosphate.

Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells.

Cyclic guanosine monophosphate (cGMP)

It is caused by a defect in the gene for cGMP-phosphodiesterase, which leads to retinal levels of cyclic guanosine monophosphate ten times normal.

As well it hinders guanylyl cyclase and therefore the forming of cyclic guanosine monophosphate (cGMP).

Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation.

This compound is a potent inhibitor of cGMP specific phosphodiesterase type 5, the enzyme that degrades the signalling molecule cyclic guanosine monophosphate.

Hydralazine increases cyclic guanosine monophosphate (cGMP) levels, increasing the activity of protein kinase G (PKG).

In his early reseach years, Dr. Murad worked on a chemical known as cyclic guanosine monophosphate, which later turned out to be critical in the nitric oxide story.

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP).

The activation of soluble guanylate cyclase by NO to produce the second messenger cyclic guanosine monophosphate (cGMP) is inhibited by methylene blue.

NO binds to soluble guanylate cyclase (sGC) and mediates the synthesis of the secondary messenger cyclic guanosine monophosphate (cGMP).

It is recognised that, by activating soluble guanylate cyclase, NO increases synthesis of cyclic guanosine monophosphate and this has been shown to produce membrane hyperpolarisation in colonic smooth muscle.

Evgeny Fesenko, Stanislav Kolesnikov, and Arkady Lyubarsky discovered in 1985 that cyclic guanosine monophosphate (cGMP) can initiate the photoresponse in rods.

The mechanism of action of sildenafil involves the protection of cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum.

Ipratropium blocks muscarinic acetylcholine receptors, without specificity for subtypes, and therefore promotes the degradation of cyclic guanosine monophosphate (cGMP), resulting in a decreased intracellular concentration of cGMP.

Isomerization of 11-cis-retinal into all-trans-retinal by light induces a conformational change (bleaching) in opsin, continuing with metarhodopsin II, which activates the associated G protein transducin and triggers a Cyclic Guanosine Monophosphate, second messenger, cascade.

Methylene blue also blocks accumulation of cyclic guanosine monophosphate (cGMP) by inhibiting the enzyme guanylate cyclase: this action results in reduced responsiveness of vessels to cGMP-dependent vasodilators like nitric oxide and carbon monoxide.

NO activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in blood vessels supplying the corpus cavernosum, resulting in increased blood flow and an erection.

This process is accelerated by a complex containing an RGS (Regulator of G-protein signaling)-protein and the gamma-subunit of the effector, cyclic GMP Phosphodiesterase.

Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase.