Cumulative toxicity is a high probability in this clinical setting.

The storage of these toxicants within the organism may lead to cumulative toxicity.

Cvitkovic E: Cumulative toxicities from cisplatin therapy and current cytoprotective measures.

The disadvantages include cumulative toxicity of ART and ATT, drug interactions leading to inflammatory reactions are the limiting factors for chosing the combination of ATT and ART.

The damage in hepatic microsomal membrane causes loss of activity of cytochrome P-450 and other membrane bound enzymes responsible for xenobiotic metabolism which leads to delayed bioelimination of sanguinarine and enhances its cumulative toxicity.