If immunoglobulins tend to precipitate within blood vessels with cold, that phenomenon takes the name of cryoglobulinaemia.

Recent reports suggest that interferon alfa can be used safely and effectively in patients with HIV infection and in patients with essential mixed cryoglobulinaemia.

Meltzer's triad describes the classical symptoms suggesting the diagnosis of cryoglobulinaemia of polyclonal CGs seen in essential-, viral-, or connective tissue disease-associated cryoglobulinaemia.