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One is stress, which increases levels in the brain of a hormone called C.R.F., or corticotropin releasing factor, which may act on the amygdala.
Stress hormones in mice such as serum corticotropin releasing factor, adrenal corticotropin releasing hormone, and corticosterone were reduced after psoralidin administration.
Neurogen is also developing a drug that acts on receptors for corticotropin releasing factor, which the brain secretes in response to threat or emergencies to set off the fight-or-flight response.
Corticotropin releasing factor (CRF), also known as Corticotropin releasing hormone, is an endogenous peptide hormone which is released in response to various triggers such as chronic stress.
They knew only that it was chemically related to corticotropin releasing factor, or C.R.F., another brain hormone, which orchestrates many of the body's responses to stress, including changes in heart rate, blood pressure, breathing, alertness and anxiety.
Ultimately the control of appetite by this mechanism is thought to be mediated by the same factors normally controlling appetite, such as neurotransmitters (serotonin, dopamine, histamine), corticotropin releasing factor, neuropeptide Y, and α-melanocyte-stimulating hormone.
When you're under stress or perceive a threat, your hypothalamus - the area of the brain that regulates the release of hormones from glands throughout your body - increases production of a substance called corticotropin releasing factor, or CRF.
A Corticotropin releasing hormone antagonist is a specific type of receptor antagonist which blocks the receptor sites for Corticotropin releasing hormone (also known as Corticotropin releasing factor (CRF)), blocking therefore the consequent secretions of ACTH and cortisol.
In a 2012 study, researchers found that the "behavioral effect [of insensole actetate] was concomitant to reduced serum corticosterone levels, dose-dependent down-regulation of corticotropin releasing factor and up-regulation of brain derived neurotrophic factor transcripts IV and VI expression in the hippocampus.
Słownik biologiczny
