cholic acid , także: cholalic acid , także: choleic acid , także: colalin

It is a conjugate of cholic acid with glycine.

Deoxycholic acid and cholic acid have also been reported.

These are manufactured from cholic acid derived from bovine bile.

Chenodeoxycholic acid and cholic acid are the most important human bile acids.

This enzyme is down-regulated by cholic acid and up-regulated by cholesterol.

These are manufactured from cholic acid derived from bovine bile, but it is said that the effect may not be the same.

The only method for preparing this drug prior to 1952 was a lengthy synthesis starting from cholic acid isolated from bile.

The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid.

Hepatocytes metabolize cholesterol to cholic acid and chenodeoxycholic acid.

Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite.

Dehydrocholic acid is a synthetic bile acid, manufactured by the oxidation of cholic acid.

(Cholic acid becomes deoxycholic acid.

There were no significant differences in the proportions of total chenodeoxycholic acid or cholic acid derivatives between the three groups (Table IV).

In the intestine, cholic acid is dehydroxylated to form the dihydroxy bile acid deoxycholic acid.

Cholic acid, along with chenodeoxycholic acid, is one of two major bile acids produced by the liver where it is synthesized from cholesterol.

This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).

The limiting molar conductance for cholic acid conjugated with either glycine or taurine is theoretically negligible considering the molar conductance of the other electrolytes.

Taurine is conjugated via its amino terminal group with chenodeoxycholic acid and cholic acid to form the bile salts sodium taurochenodeoxycholate and sodium taurocholate.

In humans, the salts of taurocholic acid and glycocholic acid (derivatives of cholic acid) represent approximately eighty percent of all bile salts.

Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into deoxycholic acid.

The balance between these two steroids determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid, both of which are secreted in the bile.

In humans, bile acid synthesis begins when liver cells synthesize the two primary bile acids, cholic acid and chenodeoxycholic acid, via the cytochrome P450-mediated oxidation of cholesterol.

SeHCAT has been shown to be absorbed from the gut and excreted into the bile at the same rate as cholic acid, one of the major natural bile acids in humans.

A defect in ileal transport mechanisms is also supported by in vivo findings suggesting a selective malabsorption of cholic acid, a primary bile acid specifically absorbed by an active transport mechanism in the terminal ileum.

The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract and, thus, improves the surfactant properties of the cholic acid conjugate.