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Pearse's main contributions lie in the structure of coated vesicles.
Clathrin is a protein that plays a major role in the formation of coated vesicles.
Components of coated vesicles and nuclear pore complexes share a common molecular architecture.
The nuclear chromatin, abundant mitochondria, reticulum and coated vesicles, had normal appearance.
This pit then buds into the cell to form a coated vesicle in the cytoplasm of the cell.
Pearse first purified coated vesicles; she also discovered the clathrin coat molecule in 1975.
Coated vesicles mediate several transport steps.
AP (adaptor protein) complexes are found in coated vesicles and clathrin-coated pits.
Coated vesicles formed from the plasma membrane have a diameter of about 36 nm and a lifetime measured in a few seconds.
Many coated vesicles and coated pits can be seen along the basolateral domain of the podocytes.
Coated vesicles were first purified by Barbara Pearse, who discovered the clathrin coat molecule.
A key protein required for endocytosis is dynamin: It assists in budding a coated pit into a cell to form a coated vesicle.
Once the coated vesicle is internalized it will shed its clathrin coat and will fuse with an acidic late endosome.
This protein is abundant in neural tissue and displays a characteristic localization to synaptic and clathrin coated vesicles.
Like the LDL receptor, the transferrin receptor is internalised into a coated vesicle.
The clathrin coated pit invaginates into the cytosol and forms a clathrin coated vesicle.
HSPA8 is ATPase that works with auxilin to remove clathrin coated vesicles.
(5) In the peri-active zone the membrane proteins are sequestered and are endocytosed forming a clathrin coated vesicle.
Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated vesicles.
After these changes, the protein is transported to the Golgi apparatus by a coated vesicle using coating protein COPII.
Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells.
Vps35 resembles many other helical solenoid proteins including AP adaptor protein complexes that are characterized with repeated structural units in a continuous superhelix arrangement involved in coated vesicle trafficking.
During interphase, CKIδ associates with the Golgi Apparatus and appears to regulate the budding of clathrin coated vesicles from the TGN; it also appears to associate with tubulin.
Apical and basolateral coated pits of MDCK cells differ in their rates of maturation into coated vesicles, but not in the ability to distinguish between hemagglutinin proteins with different internalization signals.
The conventional view of tethering/fusion assumed that the vesicle coat is shed prior to tethering and fusion but this report argues for a model where the initial tethering step takes place on a coated or partially coated vesicle.