It is possible this is the root cause of cinchonism.

Use of quinine is characterised by a frequently experienced syndrome called cinchonism.

One type of reaction (cinchonism) can occur after even a single dose of this drug.

Quinine can cause cinchonism and even death (usually by pulmonary oedema) in some cases.

Quinidine toxicity can lead to cinchonism and also to quinine amaurosis.

Most symptoms of cinchonism (except in severe cases) are reversible and disappear once quinine is withdrawn.

Symptoms of cinchonism are:

Quinidine (Class 1A anti-arrhythmic) can also cause cinchonism symptoms to develop with as little as a single dose.

Cinchonism or quinism is a pathological condition in humans caused by an overdose of quinine or its natural source, cinchona bark.

Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome.

Large doses of quinine may lead to severe symptoms of cinchonism: skin rashes, deafness (reversible), somnolence, diminished visual acuity or blindness, anaphylactic shock, and disturbances in cardiac rhythm or conduction, death from cardiotoxicity.