Toxic hepatitis and cholestatic jaundice have been reported by the manufacturer.

Estolate may cause cholestatic jaundice, although hepatotoxicity is uncommon (2% of reported cases)

Cholestatic jaundice is noted.

Rarely, cholestatic jaundice (also referred to as cholestatic hepatitis) has been associated with flucloxacillin therapy.

The E-ferol syndrome is characterised by hepatomegaly, splenomegaly, cholestatic jaundice, renal failure, and thrombocytopenia.

Hepatitis, jaundice, including cholestatic jaundice and elevated liver function tests have been reported during norfloxacin therapy.

Liver dysfunction can be limited to a reversible cholestatic jaundice and to fatty infiltration (demonstrated by elevated transaminases).

The use of clavulanic acid with penicillins has been associated with an increased incidence of cholestatic jaundice and acute hepatitis during therapy or shortly after.

Larson J, Vender R, Camuto P. Cholestatic jaundice due to ackee fruit poisoning.

Guideline for the evaluation of cholestatic jaundice in infants: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.

Gastrointestinal effects include nausea and vomiting, abdominal cramps, bloating, diarrhea, dyspepsia, dysuria, gastritis, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, or enlargement of hepatic hemangiomas.

Other side effects include gastrointestinal disturbances (e.g. diarrhea, nausea and vomiting, abdominal discomfort, disturbances in liver enzymes, transient hepatitis and cholestatic jaundice), headache, and Stevens-Johnson syndrome.

Gastrointestinal - Hepatitis, including cholestatic jaundice and hepatic necrosis, elevation of serum transaminase and bilirubin, pseudo-membranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, constipation, anorexia.