Central necrosis is often present and identifiable by imaging, especially in larger masses.

It may appear solid or cystic on imaging, frequently with central necrosis.

Often areas of central necrosis are present.

Comedocarcinoma is one kind of very early-stage breast cancer which demonstrates central necrosis.

Large tumors may undergo central necrosis, resulting in cavitation.

The tumor has a scant stroma and central necrosis because of the poor vascularization.

It then undergoes central necrosis to ulcerate.

Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.

Acne necrotica present with a primary lesions that is a pruritic or painful erythematous follicular-based papule that develops central necrosis and crusting and heals with a varioliform scar.