B) Are there determinants in morphologically normal bronchial mucosa that predict outcome?

Its expectorant action is caused by irritative action on the bronchial mucosa.

C) Can lung cancer arise directly from normal bronchial mucosa or are histopathologic intermediates required?

Found in a patient's sputum, they are ciliated columnar cells sloughed from the bronchial mucosa of a patient with asthma.

Characteristic features of atopic asthma are circulating specific IgE antibodies, positive skin tests to common allergens, and infiltration of the bronchial mucosa with eosinophils and Th2 cells.

An important advance in the understanding of extranodal lymphomas has been the description of a specific mucosa associated lymphoid tissue (MALT) that is normally present mainly in intestinal and bronchial mucosa.

Results In normal bronchial mucosa, antibodies against both proteins, MCM2 and Ki-67, generated similar patterns: some cells in the basal and parabasal layer of the bronchial epithelium displayed immunoreactivity (Fig.

These 41 specimens were used for IHC analysis and included morphologically normal bronchial mucosa, metaplasia, dysplasia, and CIS (see Table 1for the numbers of specimens with normal and abnormal morphology).

The use was based, not on the bronchodilator effect, which was discovered later, but on the vasoconstrictor effect, which was hoped to alleviate the "turgidity of the bronchial mucosa" - presumably vascular congestion and edema.