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The diagnosis can only be confirmed on bone marrow examination.
Sometimes, a bone marrow examination will include both an aspirate and a biopsy.
Responses are associated with normalization of blood counts and bone marrow examinations.
A bone marrow examination from an uninvolved site contains less than 10% plasma cells.
Detection of more than 10% of plasma cells on a bone marrow examination.
If there is a skin or soft tissue infection over the hip, a different site should be chosen for bone marrow examination.
There are few contraindications to bone marrow examination.
While mild soreness lasting 12-24 hours is common after a bone marrow examination, serious complications are extremely rare.
The technique of bone marrow examination to diagnose leukemia was first described in 1879 by Mosler.
When the diagnosis remains difficult, a bone marrow examination allows direct examination of the precursors to red cells.
Bone marrow examination is usually nondiagnostic.
Bone marrow examination or lumbar puncture may also be done to determine any metastases to bones or the brain.
Bone marrow examination may be performed on patients over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt.
Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, anemia, and pancytopenia.
Bone marrow examinations may show megaloblasts and increased erythropoiesis or bone marrow suppression.
The neutropenia was considered to be autoimmune in view of the increased neutrophil-associated IgG and active myelopoiesis on bone marrow examination.
This requires a bone marrow examination that shows normocellular (normal amounts and types of cells) blood marrow with underdeveloped promyelocytes.
The only absolute reason to avoid performing a bone marrow examination is the presence of a severe bleeding disorder which may lead to serious bleeding after the procedure.
Bone marrow examination is the pathologic analysis of samples of bone marrow obtained via biopsy and bone marrow aspiration.
Bone marrow examination including cytogenetic testing may exclude other causes of myelophthisis, such as CML, myelodysplastic syndrome, metastatic cancer, lymphomas, and plasma cell disorders.
Simpson CD, Gao J, Fernandez CV, et al.: Routine bone marrow examination in the initial evaluation of paediatric Hodgkin lymphoma: the Canadian perspective.
Myeloma is diagnosed with blood tests (serum protein electrophoresis, serum free kappa/lambda light chain assay), bone marrow examination, urine protein electrophoresis, and X-rays of commonly involved bones.
Driving his old blue Dodge, he administered Rh tests and made bone marrow examinations at many New England hospitals using materials he kept in a cigar box secured with an elastic band.
Diagnosis is usually based on repeated complete blood counts and a bone marrow examination following observations of the symptoms, however, in rare cases blood tests may not show if a patient has leukemia, usually this is because the leukemia is in the early stages or has entered remission.