The duration of action after a bolus dose may be shorter than with other routes.

We agree with the recommendation that blood samples should be taken one hour after an intravenous bolus dose.

No reduction in the bolus dose is needed.

Radiation delivery techniques (bolus doses and tangential fields) also influence the degree of reaction.

The placement of the bolus dose depends on the systemic levels of the contents desired throughout the body.

It is also important to note that large bolus doses of loop diuretics may cause transient renal vasoconstriction.

When dealing with a bolus dose (e.g. ingestion of a tablet), first order absorption is a very common assumption.

Weaning from bolus doses is achieved by decreasing the dose of morphine, not the frequency of administration, over 2 days or longer.

Participants are treated with desmoteplase as an intravenous bolus dose of 90 g/kg within three to 9 hours after stroke symptom onset.

This lasts a few seconds after administration of a bolus dose, during transient asystole induced by intravenous administration.

Bolus doses IV:

In this context it is probably most safely given by infusion since bolus doses have a propensity towards causing precipitous falls in blood pressure.

Short-term, infused, bolus doses of DCA at 50 mg/kg/day have been well tolerated.

Bolus doses must be administered slowly over 1-2 minutes to avoid bradycardia, but can be given at the same site simultaneously with dopamine, dobutamine and dextrose with electrolytes.

There are some exceptions to this rule, e.g., cisatracurium (Nimbex) is one such agent that does not elicit histamine release even up to 5xED bolus doses or continuous infusions.

This sharp downstroke overshooting towards hypoglycemia distinguishes this pathologic phenomenon from the artificial hyperglycemia inducible by an intravenous bolus dose of a large amount of glucose solution.

Five minutes after the bolus dose has been administered, an activating clotting time (ACT) should be performed and an additional bolus of 0.3 mg/kg should be given if needed.

The only perceived advantange of doxacurium over that of mivacurium is its superior cardiovascular profile, with particular reference to the lack of histamine release when administered as a rapid bolus dose.

For example if a baby is receiving 6 hourly bolus doses of morphine, these should continue to be given 6 hourly, but the amount given (mcg/kg) should be reduced over two days.

Agostinucci WA, Gannon RH, Golub GR, et al.: Continuous i.v. infusion versus multiple bolus doses of metoclopramide for prevention of cisplatin-induced emesis.

They allow a continuous infusion of small amounts of insulin to be delivered through the skin around the clock, plus the ability to give bolus doses when a person eats or has elevated blood glucose levels.

The dosage is non-physiological in that a subcutaneous bolus dose of insulin alone is administered instead of combination of insulin and C-peptide being released gradually and directly into the portal vein.

Advantages to the patient are better control over background or 'basal' insulin dosage, bolus doses calculated to fractions of a unit, and calculators in the pump that may help with determining 'bolus' infusion dosages.

Metoclopramide has also been safely given by IV bolus injection at higher single doses (up to 6 mg/kg) and by continuous IV infusion, with or without a loading bolus dose, with efficacy comparable to multiple intermittent dosing schedules.

Mivacurium is available worldwide although, in recent years, its use in the United States has declined rapidly in favor of alternative agents perceived to offer a more rapid onset of action and a safer cardiovascular profile when administered in a rapid bolus dose.