binding molecule

Tubulin binding molecules have gained much interest among cytotoxic agents due to its success in clinical oncology.

The linear isotherm occurs when the solute concentration needed to be purified is very small relative to the binding molecule.

Two individual sublibraries can be assembled combinatorially and used for the de novo identification of bindentate binding molecules.

For industrial scale uses, the total binding molecules on the column resin beads must be factored in because unoccupied sites must be taken into account.

Tubulin binding molecules have generated significant interest after the introduction of the taxanes into clinical oncology and the general use of the vinca alkaloids.

He closed his eyes, focusing his attention on the structure, feeling its texture, the rough grain of carbon crystals held together with hard plies of binding molecules.

The primary antibody can be tagged with a small molecule that can be recognised by a peroxidase-conjugated binding molecule with high affinity.

"The major problem we now face is in finding the right binding molecules," said Dr. Pastin, whose own lab has developed several pseudomonas toxin-chimeras that attack cancer cells.

A vast amount of carbohydrate binding molecules (lectins) depend on correct glycosylation for appropriate binding; the selectins, involved in leukocyte extravasation, is a prime example.

In DEL the linkage of a small molecule to an identifier DNA code allows the facile identification of binding molecules.

These activation domains are modular and can be effective when removed from one context and transplanted onto other DNA binding molecules [ 10 11 ] .

In the case of hippocampal cells, this release is dependent upon the expulsion of magnesium (a binding molecule) that is expelled after significant and repetitive synaptic signaling.

"Usually in biological research, the protein member of the pair of binding molecules is called the receptor, and physically it has a pocket in it rather like a lock.

The compound represents the core structure of a series of portable albumin binding molecules and of Albufluor a recently developed fluorescein angiographic contrast agent currently under clinical evaluation.

While the study was not able to get cystatin B past the blood-brain barrier, this method still exists as a viable option to treat ULD if the correct binding molecule is found.

CBS domains regulate the activity of associated enzymatic and transporter domains in response to binding molecules with adenosyl groups such as AMP and ATP, or s-adenosylmethionine.

In the context of a single enzyme and a pair of binding molecules, the two ligands can be compared as stronger or weaker ligands (for the enzyme) on the basis of their dissociation constants.

This can be done by chemical-shift mapping, which is seeing which resonances are shifted upon binding of the other molecule, or by cross-saturation experiments where one of the binding molecules is selectively saturated and, if bound, the saturation transfers to the other molecule in the complex.