The treatment of choice is surgical debridement and parenteral benzylpenicillin.

Overall, there are three main and important steps to the biosynthesis of penicillin G (benzylpenicillin).

Phenoxymethylpenicillin is more acid-stable than benzylpenicillin, which allows it to be given orally.

Phenoxymethylpenicillin is less active against Gram-negative bacteria than benzylpenicillin.

This derivative was later named Cephaloram, a cephalosporin analogue of benzylpenicillin.

Properties are similar to benzylpenicillin particularly used in streptococcal infections, non-resistant to penicillinase.

If meningococcal disease is suspected in primary care, guidelines recommend that benzylpenicillin be administered before transfer to hospital.

However, like methicillin, it is less potent than benzylpenicillin against non-β-lactamase-producing Gram-positive bacteria.

Treatment in primary care usually involves prompt intramuscular administration of benzylpenicillin, and then an urgent transfer to hospital for further care.

Benzylpenicillin and chloramphenicol are also effective.

This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions.

It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo.

He was given benzylpenicillin with cefotaxime and transferred to the intensive care unit, where he subsequently made an uncomplicated recovery.

Specific indications for benzylpenicillin include:

Patients treated initially with parenteral benzylpenicillin may continue oral treatment with phenoxymethylpenicillin once a satisfactory clinical response has been obtained.

Latersubgroup 2c was segregated from group 2 because these enzymes inactivate carbenicillin more than benzylpenicillin, with some effect on cloxacillin.

Benzylpenicillin serum concentrations can be monitored either by traditional microbiological assay or by more modern chromatographic techniques.

BenPen (benzylpenicillin)

If the diagnosis is suspected, especially in the presence of haemorrhagic rash, it is important to consider giving parenteral benzylpenicillin before transfer to hospital.'

Procaine penicillin and benzathine penicillin have the same antibacterial activity as benzylpenicillin but act for a longer time span.

The term "penicillin" is often used in the generic sense to refer to one of the narrow-spectrum penicillins, in particular, benzylpenicillin (penicillin G).

Benzathine is a diamine used as a component in some medications including benzathine phenoxymethylpenicillin and benzathine benzylpenicillin.

The most appropriate treatment stated in the Oxford Handbook of Clinical Medicine for rheumatic fever is benzathine benzylpenicillin.

Benzathine benzylpenicillin (rINN) is a form of penicillin also known as benzathine penicillin.

It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2-4 weeks after a single IM dose.