However, in various settings global ischemia is also relevant, e.g. in global anoxic brain damage due to cardiac arrest.

Restraint asphyxia is death or lost consciousness (to die later in a coma from anoxic brain damage), while being restrained in positions that cause asphyxia by facial compression, neck compression, or chest compression.

Partial remediation is more likely in cases with traumatic/vascular lesions, where more focal damage occurs, than in cases where the deficit arises out of anoxic brain damage, which typically results in more diffuse damage and multiple cognitive impairments.