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Rarely, angioneurotic edema and decreases in hemoglobin, red cells, and platelets have been reported.
Hepatic microsomal enzyme induction, altered lacrimation, menorrhagia, hyperkinesia, hypoesthesia and angioneurotic edema.
The term angioneurotic oedema was used for this condition in the belief that there was nervous system involvement, but this is no longer thought to be the case.
Deficiency of this protein is associated with hereditary angioedema ("hereditary angioneurotic edema"), or swelling due to leakage of fluid from blood vessels into connective tissue.
Furthermore the mechanism of focal infection theory survived in general medicine with regards to specific diseases such as tuberculosis, gonorrhea, syphilis, pneumonia, typhoid fever, and mumps as well as conditions such as idiopathic scrotal gangrene and angioneurotic edema.