This was their rationale for learning how to isolate the angioblast cells.

Here a new type of cell, the angioblast or vasoformative cell, is differentiated from the mesoderm.

VEGF promotes angioblast differentiation; whereas, VEGFR-1 stops the hemangioblast from becoming an EC.

The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells.