The microfibril scaffolds and organizes the deposition of amorphous elastin.

Fibrillin-1 is a major component of the microfibrils that form a sheath surrounding the amorphous elastin.

The elastic fiber is formed from the elastic microfibril (consisting of numerous proteins such as microfibrillar-associated glycoproteins, fibrillin, fibullin, and the elastin receptor) and amorphous elastin.

Amorphous elastin forms from monomers of soluble tropoelastin which is insolubilized and crosslinked into amorphous elastin by lysyl oxidase.