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It can present with Cushing's syndrome or primary aldosteronism.
He called it "primary aldosteronism"; it now is also known as Conn's syndrome.
Primary aldosteronism due to adrenal hyperplasia (bilateral)
CST results are used to assist in the diagnososis of primary aldosteronism (Conn Syndrome).
Conn's disease (Primary aldosteronism)
Primary aldosteronism (hyporeninemic hyperaldosteronism) was previously thought to be most commonly caused by an adrenal adenoma, termed Conn's syndrome.
A variety of adrenal cortical abnormalities can cause hypertension, In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension.
Glucocorticoid remediable aldosteronism (GRA)
Those with primary aldosteronism, and Afro-Caribbean patients (particularly those with left ventricular hypertrophy), may not benefit from an angiotensin-II receptor antagonist.
Primary aldosteronism, also known as primary hyperaldosteronism, is characterized by the overproduction of aldosterone by the adrenal glands, when not a result of excessive renin secretion.
However, in subjects with glucocorticoid-remediable aldosteronism, ACTH increases the activity of existing aldosterone synthase, resulting in an abnormally high rate of aldosterone synthesis and hyperaldosteronism.
Aldosteronism, Primary Hyperaldosteronism, Primary None Conn Syndrome is characterized by an increased level of the hormone aldosterone in the blood causing increased sodium levels in the blood.
Hyperaldosteronism, also aldosteronism, is a medical condition where too much aldosterone is produced by the adrenal glands, which can lead to lowered levels of potassium in the blood also known as hypokalemia.
Researchers said the results would soon lead to a simple blood test for the particular type of hypertension, called glucocorticoid-remediable aldosteronism, which now can be diagnosed only by a handful of experts able to perform complex enzyme measurements.
Glucocorticoid remediable aldosteronism (GRA), also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient.
Recent studies indicate that the prevalence of aldosteronism due to bilateral idiopathic adrenal hyperplasia (IAH) is higher than had previously been believed, for as many as 75% of aldosteronism cases.
"Hypokalemic Alkalosis, Hyperreninemia, Aldosteronism, Normal Blood Pressure and Normal Juxtaglomerular Apparatus : A New Syndrome of Renal Alkalosis," International Journal of Pediatric Nephrology 7: 99, 1986.