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In regards to his discovery of "Kupffer cells" in 1876, he initially suggested that this type of cell belonged to a group of perivascular cells of the connective tissues or to the adventitial cells (pericytes).
Meningoencephalitis characterized by perivascular cuffing with proliferating adventitial cells, histiocytes, and a few plasma cells was seen in the gray and white matter of the cerebrum and in the leptomeninges of PPV-infected stillborn pigs.