Natalizumab may block interaction between the α4β7 integrin and addressin at sites of inflammation.

This domain is found in mucosal vascular addressin cell adhesion molecule 1 proteins (MAdCAM-1).

Competing interests None declared Abbreviations MAdCAM-1 (mucosal addressin cell adhesion molecule-1)

Since you, no doubt bein of a more sober disposition than some drunken swabs, know how to go about addressin a lady proper, I've a mind to accord your wish.

In CD patients, sites of active inflammation of the bowel in CD patients have increased expression of addressin, suggesting a connection between the inflammation and the receptor.

The interaction of the α4β7 integrin and the addressin (also known as MADCAM1) endothelial cell receptor is believed to contribute to the chronic bowel inflammation that causes Crohn's disease.

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.

Lymphocyte homing to mucosal lymphoid tissues such as Peyer's patches, and the intestinal lamina propria involves a single-chain 60-Kd adhesion glycoprotein, the mucosal vascular addressin MAdCAM-1 [ 12, 13].

Most of them also express common markers of stromal cells such as desmin, laminin, various subunits of integrins, vascular cell adhesion molecule 1 (VCAM1) and mucosal vascular addressin cell adhesion molecule 1 (MAdCAM1).