trimethylaminuria , TMAU (skrót)
fish odor syndrome

Trimethylamine builds up in the body of patients with trimethylaminuria.

As the compound is released in a person's sweat, urine, and breath, it causes the strong odor characteristic of trimethylaminuria.

It was found that one in 15 among 200 people with odour problems investigated had a condition called trimethylaminuria - or fish odour syndrome.

Mutations in the FMO3 gene, which is found on the long arm of chromosome 1, cause trimethylaminuria.

Although FMO3 mutations account for most known cases of trimethylaminuria, some cases are caused by other factors.

Choline is a precursor to trimethylamine, which some persons are not able to break down due to a genetic disorder called trimethylaminuria.

Some people with trimethylaminuria have a strong odor all the time, but most have a moderate smell that varies in intensity over time.

Carriers may have mild symptoms of trimethylaminuria or experience temporary episodes of fish-like body odor.

Those suffering from trimethylaminuria are unable to convert choline-derived trimethylamine into trimethylamine oxide.

Persons with trimethylaminuria are advised to restrict the intake of foods high in choline; this may help to reduce the sufferer's body odor.

His current fascination is an enzyme deficiency called trimethylaminuria (TMAU), also known as fish-odor syndrome.

Most cases of trimethylaminuria appear to be inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered.

A secondary form of trimethylaminuria may result from the side effects of treatment with large doses of the amino acid derivative L-carnitine (levocarnitine).

His efforts in this area have revealed a large, undiagnosed population of people suffering from trimethylaminuria (TMAU), an odor-producing genetic disorder.

In humans, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome).

Brewster MA, Schedewie H. Trimethylaminuria.

A secondary form of trimethylaminuria is also associated with liver failure, and it has been suggested that that trimethylamine is also a contributor to the odor of fetor hepaticus.

Individuals suffering from primary trimethylaminuria lack the ability to metabolize a substance known as TMA and emit a smell that has given the disease its more common name: fish-odor syndrome [source: Reuters].

A condition similar to trimethylaminuria has also been observed in a certain breed of Rhode Island Red chicken that produces eggs with a fishy smell, especially after eating food containing a high proportion of rapeseed.

The best-known such protein is called FMO3 and is mutated in the vast majority of cases of trimethylaminuria, a genetic disease that causes deficiencies in breakdown of trimethylamine and gives the patient a fishy body odor.

He played Pugsley Addams in the 1998 film Addams Family Reunion, and had a noteworthy part on the short-lived NBC dramedy Freaks and Geeks, as secondary geek Gordon Crisp, who suffered from trimethylaminuria.

Fish Odor Syndrome Flavin Containing Monooxygenase 3 FMO, Adult Liver Form FMO3 Stale Fish Syndrome None Trimethylaminuria is a rare disorder in which the body's metabolic processes fail to alter the chemical trimethylamine.

None knew about the fish odor syndrome and thus did not ask specific questions related to it.

The diagnosis was a rare metabolic disorder called fish odor syndrome.

Fish odour syndrome, one of the most common causes of smelly perspiration and bad breath, is inherited.

It was found that one in 15 among 200 people with odour problems investigated had a condition called trimethylaminuria - or fish odour syndrome.

Trimethylaminuria ("fish odor syndrome").

In humans, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome).

The challenge in diagnosing the newest case of fish odor syndrome illustrates several problems that experts commonly encounter in evaluating patients for disorders of taste and smell.

Victims of fish odor syndrome lack the enzyme and thus accumulate trimethylamine, a breakdown product of choline that is present in beans, eggs, fish, liver and many other foods.

Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production of the enzyme flavin containing monooxygenase 3 (FMO3).

Fish Odor Syndrome Flavin Containing Monooxygenase 3 FMO, Adult Liver Form FMO3 Stale Fish Syndrome None Trimethylaminuria is a rare disorder in which the body's metabolic processes fail to alter the chemical trimethylamine.

When the woman with the fish taste problem went to the Syracuse center, "the diagnosis of fish odor syndrome didn't occur to us on the first visit," Dr. Leopold said in an interview elaborating on his team's report in the March issue of Archives of Otolaryngology and Head and Neck Surgery.