RNA splicing

RNA splicing takes place after transcription and before translation.

Introns and the process of RNA splicing can be illustrated using a text example.

RNA splicing joins the recombined region with the C segment.

RNA splicing is a stage in gene transcription.

The control of alternative RNA splicing is performed by complex network of signalling molecules.

RNA splicing is dependent upon the identity of nucleotide sequences at the exon/intron boundaries.

He showed that RNA splicing is the mechanism for generating the membrane bound and the secreted forms of antibodies.

Alterations in RNA splicing have been noted previously in transformed human cells (8), metastasizing tumor cells (29), and in a number of inherited diseases.

Although most RNA splicing occurs after the complete synthesis and end-capping of the pre-mRNA, transcripts with many exons can be spliced co-transcriptionally.

When proteins are generated from intron-containing genes, RNA splicing takes place as part of the RNA processing pathway that follows transcription and precedes translation.

RNA splicing removes the non-coding RNA introns leaving behind the coding sequences exons, which are then spliced and joined together to form the final mRNA.

Alternative RNA Splicing of this late transcript is essential for L1 and L2 expression and can be regulated by RNA cis-elements and host splicing factors.

In 1977, introns and RNA splicing were discovered in both mammalian viruses and in cellular genes, resulting in a 1993 Nobel to Philip Sharp and Richard Roberts.

The discovery of discontinuous genes and RNA splicing was entirely unexpected by the community of RNA biologists, and stands as one of the most shocking findings in molecular biology research.

RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Supporters of the "introns early theory" believed that introns and RNA splicing were the relics of the RNA world and therefore both prokaryotes and eukaryotes had introns in the beginning.

Additionally, Hood was the first to study, at the gene level, the MHC (major histocompatibility complex) gene family and the T-cell receptor gene families as well as the first to demonstrate that alternative RNA splicing was a fundamental mechanism for generating alternative forms of antibodies.