One domain in particular contains a high structural similarity to fibrillin containing an RGD sequence, which is known to be involved in adhesion to membrane bound integrins.

The protein also contains type II repeats with epidermal growth factor-like homology and type III repeats that contain an RGD sequence.

This RGD sequence on endoglin is the first RGD sequence identified on endothelial tissue.

This particular domain contains the RGD sequence important in the binding of ECM protiens to integrins found in cell membranes, an important feature in cellular adhesion.

Collagen originated sequence is DGEA and many other ECM protein originated RGD sequence can be given as other examples.