Parinaud's syndrome

Parinaud's Syndrome results from injury, either direct or compressive, to the dorsal midbrain.

Dorsal midbrain structures, as in Parinaud's syndrome.

It should not be confused with the neurological syndrome caused by a lesion in the midbrain which is also known as Parinaud's syndrome.

Parinaud's Syndrome is a cluster of abnormalities of eye movement and pupil dysfunction, characterized by:

A pineal tumor can compress the superior colliculi and pretectal area of the dorsal midbrain, producing Parinaud's syndrome.

The eye findings of Parinaud's Syndrome generally improve slowly over months, especially with resolution of the causative factor; continued resolution after the first 3-6 months of onset is uncommon.

He is well known for the medical term Parinaud's syndrome, which is, "A dorsal midbrain lesion such as pinealoma which results in vertical gaze palsy, convergence-retraction nystagmus and light-near dissociation".

Causes include upper dorsal midbrain supranuclear lesions such as Parinaud's syndrome, 'top of the basilar syndrome', midbrain infarction, neurodegeneration or tumour, Multiple Sclerosis, encephalitis, and Miller-Fisher Syndrome.