This may be due to its potential to inhibit P-glycoprotein.

Research on p-glycoprotein and other such chemotherapy efflux pumps is currently ongoing.

Efflux is caused by P-glycoprotein called also the multidrug transporter.

St Johns wort increases expression of P-glycoprotein: implications for drug interactions.

Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

The transporter P-glycoprotein exists already in the embryonal endothelium.

P-glycoprotein is a well-studied protein associated with multi-drug resistance.

He is best known for his discovery of P-glycoprotein, one of the proteins responsible for multidrug resistance.

Drug resistance associated with drug efflux, mediated by P-glycoprotein, was originally reported in mammalian cells.

P-glycoprotein is the best-studied efflux pump and as such has offered important insights into the mechanism of bacterial pumps.

It has been found that bevirimat does not inhibit the cytochrome P450 system or interact with the human P-glycoprotein.

The P-glycoprotein "works like a bilge pump," Dr. Salmon said.

Alvimopan is substrate for p-glycoprotein.

Omeprazole is also a competitive inhibitor of p-glycoprotein, as are other PPIs.

Nilotinib is also not a substrate for the efflux transporter P-glycoprotein pump, unlike imatinib.

Dasatinib is also not a substrate of multidrug P-glycoprotein efflux pumps like imatinib.

P-glycoprotein has affinity to hydrophobic drags with positive charge or electrically neutral and is often over-expressed in many human cancers.

It may also induce P-glycoprotein, which may affect drugs transported by Pgp, such as digoxin.

P-glycoprotein is expressed primarily in certain cell types in the liver, pancreas, kidney, colon, and jejunum.

It is a substrate of P-glycoprotein (Pgp), which is usually overexpressed in cancer cells.

Verapamil is also used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein.

The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.

Medications to inhibit the function of p-glycoprotein are undergoing testing as of June, 2007 to enhance the efficacy of chemotherapy.

Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.

For a few drugs, grapefruit activates another digestive chemical, P-glycoprotein, and may prevent full amounts of the drugs from entering the bloodstream.