Clemmensen reduction

The Clemmensen reduction is particularly effective at reducing aryl-alkyl ketones.

It may be derived by Clemmensen reduction from cycloheptanone.

The substrate must be stable in the strongly acidic conditions of the Clemmensen reduction.

One route to prolintane involves Clemmensen reduction of the pyrovalerone compound.

See also Clemmensen reduction.

The acylated reaction product can be converted into the alkylated product via a Clemmensen reduction.

In the Clemmensen reduction of ketones to alkanes with zinc-mercury amalgam, the intermediate is an organozinc carbenoid.

For the invention of the Clemmensen reduction, he received his Ph.D. in 1913 from the University of Copenhagen.

Substituted zinc carbenoids can be prepared from the corresponding ketones or aldehydes through a sequence analogous to the mechanism of the Clemmensen reduction.

Ketones and aldehydes can also be reduced to alkanes using a zinc amalgam and hydrochloric acid via the Clemmensen reduction.

Clemmensen reduction is a chemical reaction described as a reduction of ketones (or aldehydes) to alkanes using zinc amalgam and hydrochloric acid.

If desired, the resulting ketone can be subsequently reduced to the corresponding alkane substituent by either Wolff-Kishner reduction or Clemmensen reduction.

The Clemmensen reduction is avoided if the synthesis starts with alkylation of BnCN followed by hydrolysis and reductive amination.