Clara cell

In addition to being structurally diverse, Clara cells are also functionally variable.

This protein is specifically expressed in Clara cells in the lungs.

Clara cells are found in the ciliated simple epithelium.

Clara cells also produce a component of lung surfactant.

One of the main functions of Clara cells is to protect the bronchiolar epithelium.

Terminal bronchioles are lined with simple cuboidal epithelium containing Clara cells.

"Clara cells" were originally described by their namesake, Max Clara in 1937.

Clara cells accomplish this with cytochrome P450 enzymes found in their smooth endoplasmic reticulum.

It appears to selectively target Clara cells, which are the major site of cytochrome P450 enzymes in the lungs.

In 1937, he discovered previously unknown cells found in human lungs, which were later eponymously named Clara cells.

The heterogeneous nature of the dense granules within the Clara cell's cytoplasm suggests that they may not all have a secretory function.

Clara cells are mitotically active cells.

Clara cells are non-ciliated, rounded protein secreting cells.

Clara cells are dome-shaped cells with short microvilli found in the small airways (bronchioles) of the lungs.

Clara cells, a stem cell of the respiratory system, produce enzymes that detoxify substances dissolved in the respiratory fluid.

TTF-1 positive cells are found in the lung as type II pneumocytes and Clara cells.

To confirm this possibility, in situ hybridization with a probe specific for type II pneumocytes and Clara cells was performed.

Clara cells also act as a stem cell and multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.

Specifically, Type-2 pneumocytes and Clara Cells of the lung are the likely target for JSRV transformation.

Their failure to identify lamellar bodies and large dense granules seemed to rule out origination from either Clara cells or Type II pneumocytes.

In non-mucinous BAC, neither Clara cell nor Type II pneumocyte differentiation appears to affect survival or prognosis.

These results strongly indicate that type II pneumocytes and Clara cells are the sources of ATPase 6 over-expression during P. carinii infection.

The apical areas are where type II pneumocytes are located, and the very distal parts of the respiratory tree are where Clara cells are located.

They are histologically distinct from the tertiary bronchi in that their walls do not have hyaline cartilage and they have Clara cells in their epithelial lining.

We also found that type II pneumocytes and Clara cells are responsible for over-expression of the ATPase 6 gene in P. carinii -infected rat lung.