Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.).

In an in vitro model using HL-60leukemia cells, protocatechuic acid showed an antigenotoxic effect and tumoricidal activity.

"Clasically activated" M1 macrophages are microbicidal and tumoricidal, and stimulate adaptive immune response.

HAMLET is a novel chemotherapeutic agent with potent tumoricidal properties.

The active component responsible for the tumoricidal activity was finally elucidated in 2000 and found to be a complex of alpha-lactalbumin and oleic acid.

The tumoricidal properties of β-glucans have been studied in several in vitro and in vivo animal models.

Leucovorin rescue is a therapeutic maneuver intentionally employed with antifolates to achieve tumoricidal drug concentrations that would otherwise be lethal to the patient.

Endogenous human alpha-lactalbumin is complexed with a calcium ion and serves as a cofactor in lactose synthesis, but has no tumoricidal properties.

The potential tumoricidal and antiviral properties of HAMLET would make it indispensable for an immune naïve infant.

Tuftsin binds to specific receptors on the surface of macrophages and polymorphonuclear leukocytes, stimulating their migration, phagocytic, bactericidal, and tumoricidal activity.

In macrophages, NO mediates tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects.

Washburn B, Weigand MA, Grosse-Wilde A, et al.: TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus.

The mycelial endopolysaccharide of I. obliquus was identified as a candidate for use as an immune response modifier and indicated the anticancer effect of endopolysaccharide is not directly tumoricidal, but rather is immunostimulation.

Teo PM, Leung SF, Lee WY, et al.: Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma: the existence of a dose-tumor-control relationship above conventional tumoricidal dose.

The function of TAMs is controversial as there is growing evidence for their involvement in both pro-tumor (e.g. promotion of growth and metastasis through tumor angiogenesis) as well as anti-tumor (tumoricidal and tumorostatic) processes.