Originally described as stiff-man syndrome, the name was changed to reflect that the disorder can affect individuals of any age and of either gender.

Several: Spastic, Spastic Diaplega, Stiff-man syndrome, etc.

Stayer C, Tronnier V, Dressnandt J, et al.: Intrathecal baclofen therapy for stiff-man syndrome and progressive encephalomyelopathy with rigidity and myoclonus.

Stiff-man syndrome is a neurologic disorder caused by anti-GAD antibodies, leading to a decrease in GABA synthesis and, therefore, impaired motor function such as muscle stiffness and spasm.

Stiff person syndrome (SPS) (or stiff-man syndrome; also known as Moersch-Woltman Condition) is a rare neurologic disorder of unknown etiology characterized by progressive rigidity and stiffness, primarily of the axial musculature, that is superimposed by spasms, resulting in postural deformities.

Physical therapy is another treatment option for people with stiff person syndrome.

Individuals with stiff person syndrome tend to present in 3 different stages: early, late and end stage.

The following differential diagnoses should also be considered when suspecting stiff person syndrome.

And if a person produces auto-antibodies against gephyrin, this can even result in stiff person syndrome.

A mutation in GLRA1 is responsible for some cases of stiff person syndrome.

Reflexive integrity in individuals with stiff person syndrome can be assessed via deep tendon reflexes as well as resistance to passive stretch.

Stiff person syndrome (SPS) (or stiff-man syndrome; also known as Moersch-Woltman Condition) is a rare neurologic disorder of unknown etiology characterized by progressive rigidity and stiffness, primarily of the axial musculature, that is superimposed by spasms, resulting in postural deformities.

The field of Movement Disorders includes the following areas: Parkinson's disease and Parkinsonism, ataxia, dystonia, chorea and Huntington's disease, tics and Tourette syndrome, myoclonus and startle, restless leg syndrome, stiff person syndrome, tremor and essential tremor, and gait disorders.

This gene may also play a role in the stiff man syndrome.

Therapeutic exercises for people with stiff man syndrome would likely include a stretching program to help patients gain range of motion by reducing muscle spasms and muscle stiffness.